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四季菜(Artemisia Lactiflora Wall ex Dc)具护肝作用的有效成份是7-甲氧基香豆素(herniarin)。笔者对原提取工艺进行了改进,认为醇提比水提好,并考虑了乙醇浓度,乙醇用量,热回流时间三个因子,按正交试验法设计L_9(3~4)表,考察分析了浸膏得率,有效成分得率两个指标,经验证试验结果证明A_3B_3C_1为最佳提取工艺方案,即乙醇浓度为70％,乙醇溶液用量为生药的17倍量,回流时间共3h,每次1.5h。
The active ingredient of Artemisia Lactiflora Wall ex Dc that protects the liver is 7- methoxy coumarin (herniarin). The author has improved the original extraction process, and concluded that the alcohol extraction is better than water, and considering the three factors of ethanol concentration, ethanol dosage, and heat reflux time, the L_9 (3~4) table was designed according to the orthogonal test method and analyzed. The extract yield and effective ingredient yield were two indicators. The results of the validation test proved that A_3B_3C_1 was the best extraction process, ie, the ethanol concentration was 70%, the ethanol solution amount was 17 times the crude drug, and the reflux time was 3 hours. 1.5h.