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目的探讨黄芪注射液对慢性阻塞性肺疾病(COPD)急性加重期患者氧化应激和炎性反应状态的改善效果。方法选取COPD急性加重期患者46例,随机分为试验组和对照组各23例,试验组给予综合治疗和3次/周的黄芪注射液10ml静脉注射,对照组给予综合治疗,未给予黄芪注射液治疗,观察4周时间,另设年龄、性别相匹配的健康组予以对照。治疗前后检测患者的氧化应激指标丙二醛(MDA)、超氧化物歧化酶(SOD)、C-反应蛋白(CRP)、白介素-6(IL-6)水平,并对照分析。结果COPD急性加重期患者的MDA、CRP、IL-6水平高于健康组,SOD低于健康组,差异明显,具有统计学意义(P<0.05);试验组治疗前后MDA、SOD、IL-6有明显差异,具有统计学意义(P<0.05)。结论黄芪注射液可全面改善COPD急性加重期患者的氧化应激和炎性反应状态。
Objective To investigate the effect of astragalus injection on oxidative stress and inflammatory reaction in patients with acute exacerbation of chronic obstructive pulmonary disease (COPD). Methods Forty-six patients with acute exacerbation of COPD were randomly divided into experimental group and control group, with 23 cases in each group. The experimental group received 10 ml intravenous injection of Astragalus injection and 3 ml / week Astragalus injection. The control group received no treatment with astragalus injection Liquid treatment, observed for 4 weeks, another set of age, gender-matched healthy group to be controlled. The levels of malondialdehyde (MDA), superoxide dismutase (SOD), C-reactive protein (CRP) and interleukin-6 (IL-6) were measured before and after treatment. Results The levels of MDA, CRP and IL-6 in patients with acute exacerbation of COPD were significantly higher than those in healthy controls and SOD were lower than those in healthy controls (P <0.05) There are significant differences, with statistical significance (P <0.05). Conclusion Astragalus injection can completely improve the oxidative stress and inflammatory reaction in patients with acute exacerbation of COPD.