泛素-蛋白酶体系统(ubiquitin-proteasome system,UPS)是细胞内蛋白质降解的主要途径,参与细胞内80%以上蛋白质的降解。UPS在错误折叠蛋白或其他突变蛋白的降解过程中也发挥重要作用。神经退行性疾病的共同特征是突变或损伤蛋白在细胞内或细胞外的异常聚集,临床上常见的有阿尔 Ubiquitin-proteasome system (UPS) is the main pathway of protein degradation in cells, which is involved in the degradation of over 80% of proteins in cells. UPS also plays an important role in the degradation of misfolded proteins or other muteins. The common feature of neurodegenerative diseases is the abnormal accumulation of mutations or impaired proteins in the cells or extracellularly. Alzheimer’s