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目的探讨ｃ－ｅｒｂＢ－２及ＰＣＮＡ的表达与大肠癌生物学行为的关系。方法利用微波免疫组织化学染色技术，检测ｃ－ｅｒｂＢ－２及ＰＣＮＡ在４２例大肠癌中的表达，并对数据进行χ２检验。结果ｃ－ｅｒｂＢ－２与大肠癌的分化程度有关（Ｐ＜０．０５），ＰＣＮＡ在低分化腺癌及淋巴结有转移的大肠癌中有增高趋势，另外，ｃ－ｅｒｂＢ－与ＰＣＮＡ两者表达一致性占６６．７％（Ｐ＜０．０５），表明在细胞增殖旺盛过程中，癌基因可能容易被激活。结论ｃ－ｅｒｂＢ－与ＰＣＮＡ一起可作为判断肿瘤的恶性程度及评价预后的有用指标。
Objective To investigate the relationship between the expression of c-erbB-2 and PCNA and the biological behavior of colorectal cancer. Methods The expression of c-erbB-2 and PCNA in 42 cases of colorectal cancer was detected by microwave immunohistochemistry. The data were analyzed by Chi-square test. Results c-erbB-2 was associated with the degree of differentiation of colorectal cancer (P<0.05). PCNA increased in poorly differentiated adenocarcinoma and colorectal cancer with lymph node metastasis. In addition, both c-erbB- and PCNA were expressed. Concordance accounted for 66.7% (P<0.05), indicating that oncogenes may be easily activated during cell proliferation. Conclusion c-erbB-and PCNA can be used as a useful indicator to judge the malignancy of tumors and evaluate their prognosis.