肝原发性鳞状细胞癌是极为罕见的,本文报告1例肝原发性鳞状细胞癌的发生与多发性肝内胆石有关,迄今未见有过报告。患者男性,43岁。15个月内3次发作黄疸,每次发作均伴有深色尿,淡色大便,无瘙痒。在第2、3次发作时并有右季肋部及上腹部刀刺样痛。3个月内体重下降12kg。检查病人无发热,肝在右肋下4 cm、剑突下12cm,质硬,无触痈。未听到血管杂音,脾不大,无腹水。胸透示右膈轻度升高,腹部平片无肝钙化。右肺底有肺不张。血红蛋白11.4g/dl,白细胞24.6×10~9/L,凝血酶原指数85%,总血清胆红素24μmol/L,碱性磷酸酶540(正常30～100)IU/L,γ- Primary squamous cell carcinoma of the liver is extremely rare. One case of primary squamous cell carcinoma of the liver was reported to be associated with multiple intrahepatic gallstones. No report has been made so far. The patient male is 43 years old. Three episodes of jaundice occurred within 15 months. Each episode was accompanied by dark urine, light-colored stool, and no itching. On the 2nd and 3rd episodes, there were stabbing pains in the right quarter rib and upper abdomen. Within 3 months weight loss 12kg. The patient was examined for no fever. The liver was 4 cm below the right rib and 12 cm below the xiphoid. It was hard and not touched. No vascular murmurs were heard, and the spleen was not large and ascites. Chest penetration showed a slight increase in the right iliac crest, and the abdominal plain film had no hepatic calcification. There is atelectasis at the right lung floor. Hemoglobin 11.4g/dl, WBC 24.6×10~9/L, prothrombin index 85%, total serum bilirubin 24μmol/L, alkaline phosphatase 540 (normal 30～100) IU/L, γ-