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[目的]探讨非酒精性脂肪肝病(NAFLD)与冠状动脉动脉粥样硬化病变的关系。[方法]84例疑诊冠心病患者同时检测血生化指标、肝脏超声和行冠脉CTA检查,并将患者分为NAFLD组(97例)和非NAFLD组(87例),比较2组一般情况、冠心病患病率、冠脉病变特点,采用二分类Logistic回归分析冠心病的危险因素。[结果]NAFLD组体质指数、吸烟率、糖尿病和高血压病患病率、TC、TG、ALT水平均明显高于非NAFLD组(P<0.05)。NAFLD组冠心病患病率、多支病变率及非钙化斑块率均高于非NAFLD组(P<0.05)。多因素Logistic回归分析显示NAFLD增加冠心病发病风险[P=0.013,OR=4.116,95%CI(1.904~9.270)]。[结论]NAFLD是冠心病独立危险因素,且与冠脉病变严重程度相关。
[Objective] To investigate the relationship between non-alcoholic fatty liver disease (NAFLD) and coronary artery atherosclerosis. [Methods] Eighty-four patients with suspected coronary heart disease were simultaneously tested for blood biochemical markers, liver ultrasound and coronary CTA. The patients were divided into NAFLD group (n = 97) and non-NAFLD group (n = 87) , The prevalence of coronary heart disease and the characteristics of coronary artery disease. Logistic regression analysis was used to analyze the risk factors of coronary heart disease. [Results] The body mass index, smoking prevalence, prevalence of diabetes and hypertension, TC, TG and ALT in NAFLD group were significantly higher than those in non-NAFLD group (P <0.05). The prevalence of coronary heart disease, multivessel disease and non-calcified plaque in NAFLD group were higher than those in non-NAFLD group (P <0.05). Multivariate logistic regression analysis showed that NAFLD increased the risk of coronary heart disease (P = 0.013, OR = 4.116, 95% CI 1.904-9.270). [Conclusion] NAFLD is an independent risk factor for coronary heart disease and is related to the severity of coronary artery disease.