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目的进一步明确慢性化脓性中耳炎病源菌分布和药物敏感性,加强临床抗生素应用的针对性和有效性。方法对符合诊断标准的158例慢性化脓性中耳炎患者进行病源菌检测和药敏试验。结果病原菌检出率94.94%,细菌占96.67%,真菌占3.33%;共培养分离出致病菌176株,排序前4位的是金黄色葡萄球菌28株(15.91%),铜绿假单胞菌27株(15.34%),凝固酶阴性葡萄球菌22株(12.50%),变形杆菌20株(11.36%);致病菌对青霉素和第一代头孢类药物敏感性较低,对万古霉素、亚胺培南、哌拉西林的敏感性达100%。结论慢性化脓性中耳炎以金黄色葡萄球菌,铜绿假单胞菌,凝固酶阴性葡萄球菌,变形杆菌为主要致病菌,细菌培养和药敏试验有助于指导临床用药。
Objective To further clarify the distribution of pathogens and drug sensitivity in chronic suppurative otitis media, and to improve the pertinence and effectiveness of clinical antibiotics. Methods 158 cases of chronic suppurative otitis media in line with the diagnostic criteria for pathogen detection and drug susceptibility testing. Results The detection rate of pathogenic bacteria was 94.94%, accounting for 96.67% for bacteria and 3.33% for fungi. 176 strains of pathogenic bacteria were isolated from co-culture, 28 strains (15.91%) of Staphylococcus aureus, 27 (15.34%), coagulase-negative Staphylococcus 22 (12.50%) and Proteus 20 (11.36%). The pathogenic bacteria were less sensitive to penicillin and the first generation cephalosporins, Imipenem, piperacillin sensitivity of 100%. Conclusion Chronic otitis media with Staphylococcus aureus, Pseudomonas aeruginosa, coagulase-negative Staphylococcus aureus, Proteus as the main pathogens, bacterial culture and susceptibility testing help to guide the clinical use of drugs.