因人-人单克隆抗体较难制备,英国剑桥大学分子生物学家Winter正在研究把小鼠单克隆抗体人类化.他采用多位点定向突变把鼠抗体分子转变成人抗体.该单克隆结构能治疗爱滋病(AIDS).Winter进一步说明,抗体分子由一个决定其结构的恒定区和一个决定其与抗原的反应性的可变区构成,而可变区又由支架区和其特异性所在的互补区组成. Because human-human monoclonal antibodies are harder to make, Winter, a molecular biologist at the University of Cambridge in the United Kingdom, is studying the humanization of mouse monoclonal antibodies using multi-site directed mutagenesis to convert murine antibody molecules into human antibodies. AIDS. "Winter further states that an antibody molecule consists of a constant region that defines its structure and a variable region that determines its reactivity with the antigen, which in turn is complemented by the region of the scaffold and its specificity District composition.