论文部分内容阅读
目的:探讨PTEN、caspase-3在胃癌组织中的表达及其与临床病理特征之间的相关性。方法:用免疫组织化学Envison法检测73例胃癌及20例正常胃黏膜组织中PTEN、caspase-3的表达情况。结果:①PTEN和caspase-3在胃癌组织中表达下调,阳性表达率分别为39.7%(29/73)和21.9%(16/73)。②PTEN表达随肿瘤分化程度的降低、浸润深度加深、淋巴结转移增多、临床分期提高而降低,青年组比中老年组表达低。③caspase-3阳性表达随肿瘤分化程度的降低、临床分期提高而降低。④胃癌组织中PTEN与caspase-3的表达呈正相关(r=0.653,P<0.01)。结论:PTEN、caspase-3的表达下调与胃癌的发生、发展有关,二者可作为判定胃癌生物学行为和预后的临床参考指标。
Objective: To investigate the correlation between the expression of PTEN and caspase-3 in gastric carcinoma and their clinicopathological features. Methods: The expressions of PTEN and caspase-3 in 73 cases of gastric cancer and 20 cases of normal gastric mucosa were detected by Envison immunohistochemistry. Results: ① The expressions of PTEN and caspase-3 were down-regulated in gastric cancer tissues, the positive rates were 39.7% (29/73) and 21.9% (16/73), respectively. ② PTEN expression decreased with the degree of tumor differentiation, depth of invasion, lymph node metastasis increased, clinical stage increased and decreased, young group than in the elderly group was low expression. ③ Caspase-3 positive expression decreased with the degree of tumor differentiation, clinical stage increased and decreased. ④ The expression of PTEN and caspase-3 in gastric cancer tissues was positively correlated (r = 0.653, P <0.01). Conclusion: The down-regulation of PTEN and caspase-3 may be related to the occurrence and development of gastric cancer, both of which may be used as clinical reference indexes to judge the biological behavior and prognosis of gastric cancer.