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目的:研究并分析治疗腹泻型肠易激综合征患者时使用布拉氏酵母菌、马来酸曲美布丁结合治疗的效果。方法:收集腹泻型肠易激综合征患者共90例,按照完全随机化分组原则将其分为对照组(45例)和观察组(45例),对照组的治疗药物为马来酸曲美布丁,观察组联合布拉氏酵母菌,将两组每日腹泻次数、急性应激次数、不良反应发生率进行观察和对比。结果:相较于对照组,观察组的每日腹泻次数、急性应激次数均更少,P均<0.05;在不良反应发生率方面,观察组与对照组无显著差异,P>0.05。结论:在腹泻型肠易激综合征患者的治疗过程中,布拉氏酵母菌、马来酸曲美布丁结合治疗能够显著降低患者的腹泻次数,疗效显著其安全性高,值得推广应用。
OBJECTIVE: To study and analyze the efficacy of combination therapy with S. cerevisiae and trimebutine maleate in the treatment of patients with diarrhea-predominant irritable bowel syndrome. Methods: Totally 90 patients with diarrhea-predominant irritable bowel syndrome were divided into control group (45 cases) and observation group (45 cases) according to the principle of complete randomization. The control group was treated with trimebutine maleate Pudding, observation group combined with B. Cerevisiae, the two groups daily diarrhea, the number of acute stress, the incidence of adverse reactions were observed and compared. Results: Compared with the control group, the number of diarrhea and the number of acute stress in the observation group were all less than those in the control group (P <0.05). There was no significant difference in the incidence of adverse reactions between the observation group and the control group (P> 0.05). Conclusion: In the course of treatment of patients with diarrhea-predominant irritable bowel syndrome, the combined treatment of S. cereus and trimebutine maleate can significantly reduce the frequency of diarrhea in patients with diarrhea-type irritable bowel syndrome. The therapy is remarkably safe and worthy of promotion.