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摘要目的评估胸片或CT上有或无孤立性肺结节(SPN)的病人的肺癌风险和特异性死亡率。方法回顾性分析≥35岁的16 078例病人的影像资料(其中893例胸片或CT提示有SPN,15 185例无SPN)。病人随访18个月或直至被诊断为肺癌。两组病人的风险和肺癌死亡率用Poisson回归计算。结果平片和CT上存在SPN组病人,肺癌发生率分别为8.3%(95%CI:6.0~11.2)、12.4%(95%CI:9.3~15.9)。慢性阻塞性肺疾病病人的X线片(OR,2.62;95%CI:1.03~6.67)和吸烟(OR,20.63;95%CI:3.84~110.77)病人的CT与肺癌相关的概率较高。CT和胸片上提示的大结节和周边毛刺与肺
Abstract Objective To assess the lung cancer risk and specific mortality in patients with and without solitary pulmonary nodules (SPN) on chest radiographs or on CT. Methods We retrospectively analyzed the imaging data of 16 078 patients aged 35 years and older (893 cases of chest radiograph or CT showed SPN and 15 185 cases without SPN). Patients were followed up for 18 months or until diagnosed with lung cancer. The risk of both groups of patients and lung cancer mortality were calculated using Poisson regression. Results The incidence of lung cancer was 8.3% (95% CI: 6.0 ~ 11.2) and 12.4% (95% CI: 9.3 ~ 15.9) respectively in plain film and SPN group on CT. Patients with chronic obstructive pulmonary disease have a higher probability of CT associated with lung cancer on radiographs (OR, 2.62; 95% CI: 1.03 to 6.67) and smoking (OR, 20.63; 95% CI: 3.84 to 110.77). Nodules and peripheral glitches and lungs are indicated on CT and chest radiographs