对化学致癌剂２－ＦＡＡ诱发鼠肝癌过程中血清、肝组织中ＧＰＤＡ总活性进行动态观察。在肝脏由癌前病变到癌变过程中，早期血清ＧＰＤＡ总活性升高，肝细胞可溶性ＧＰＤＡ减少；后期血清和肝组织中ＧＰＤＡ总活性均升高。研究结果提示，实验鼠肝癌血清ＧＰＤＡ总活性升高，早期是肝细胞释放增加，后期是肝细胞合成增加并释放入血。 The activity of GPDA in serum and liver tissue during the process of 2-FAA-induced liver cancer induced by chemical carcinogen was dynamically observed. In the liver from the precancerous lesion to the carcinogenesis, the total serum GPDA activity increased early, and the soluble hepatocyte GPDA decreased; the total activity of GPDA in the serum and liver tissue increased later. The results of the study suggest that the serum GPDA total activity of hepatoma in experimental rats is increased, and the early release of hepatocytes is increased, and the synthesis of hepatocytes is increased and released into the blood at the later stage.