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奥美拉唑是一种新型H~+K~+-ATP 酶拮抗剂,能强有力地抑制胃酸分泌,治疗重症反流性食管炎及卓-艾氏综合征疗效显著。本文首次报告奥美拉唑引起暴发性肝衰竭1例。病例报告患者男,62岁,因中上腹及右上腹疼痛伴返酸就诊。腹部超声、转氨酶、碱性磷酸酶及胆红素均正常。口服雷尼替丁150mg 每日二次,10天无缓解。内窥镜检查示腐蚀性食管炎伴轻度胃窦炎及十二指肠炎。遂停用雷尼替丁,换服奥美拉唑每日20mg。17天后自感上腹痛加剧、厌食、恶心、呕吐、乏力和头晕。询问病史,患者既往患高血压和冠心病,1年来持续服用氨酰心安100mg,每日一次,
Omeprazole is a novel H ~ + K ~ + -ATPase antagonist, can strongly inhibit gastric acid secretion, the treatment of severe reflux esophagitis and Zhuo - Ehrlich syndrome significant effect. This is the first report of omeprazole in 1 case of fulminant hepatic failure. Case Report Male, 62 years old, with upper back and right upper quadrant pain with acid reflux treatment. Abdominal ultrasound, aminotransferase, alkaline phosphatase and bilirubin were normal. Oral ranitidine 150mg twice daily, no relief for 10 days. Endoscopic examination showed corrosive esophagitis with mild gastritis and duodenitis. Then disable ranitidine, change service omeprazole daily 20mg. After 17 days, upper abdominal pain intensified, anorexia, nausea, vomiting, fatigue and dizziness. Ask history, patients with previous history of hypertension and coronary heart disease, a year of continuous use of atenolol 100mg, once daily,