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目的观察参射汤（中药合剂）配合放射治疗鼻咽癌，能否改善患者在放射治疗中的副反应并提高患者的远期生存率。方法１９８４年６月～１９９３年６月用参射汤配合放射治疗鼻咽癌研究，参射汤＋放射治疗３５１例（Ａ组），单纯放射治疗６０例（Ｂ组）。结果随访结果分析，Ａ组和Ｂ组病例口腔粘膜出现白膜反应分别为８．３％（２９／３５１）和３１．７％（１９／６０）；粘膜溃疡分别为２．０％（７／３５１）和４８．３％（２９／６０）；吃干饭分别为９３．２％（３２７／３５１）和１０．０％（６／６０）；吃半流分别为５．１％（１８／３５１）和３８．３％（２３／６０）；吃全流分别为１．７％（６／３５１）和５１．７％（３１／６０）。５年生存率Ａ组和Ｂ组分别为６６．７％（２３４／３５１）和４８．３％（２９／６０）。２个组比较差异有显著意义（Ｐ＜０．０１）。结论研究显示用参射汤配合放射治疗鼻咽癌，能降低患者放射治疗反应，提高生存率并无远期毒性反应。
Objective To observe whether Shen-Shoup (TCM mixture) combined with radiotherapy of nasopharyngeal carcinoma can improve patients’ side effects in radiation therapy and improve the long-term survival rate of patients. Methods From June 1984 to June 1993, Shen-Shiting Decoction combined with radiotherapy was used to treat nasopharyngeal carcinoma. 351 cases were treated with Shen-Shou Tang + radiotherapy (group A) and 60 cases were treated with radiotherapy alone (group B). Results The results of follow-up analysis showed that the oral mucosa of group A and group B had a rate of 8.3% (29/351) and 31.7% (19/60), respectively. Mucosal ulceration was 2.0% (7 / 351) and 48.3% (29/60) respectively. The rates of eating dry rice were 93.2% (327/351) and 10.0% (6/60) ) And 38.3% (23/60) respectively. The prevalence of eating whole-body was 1.7% (6/351) and 51.7% (31/60) respectively. The 5-year survival rates in group A and group B were 66.7% (234/351) and 48.3% (29/60), respectively. The difference between the two groups was significant (P <0.01). Conclusions The study shows that the combination of Shen-Shou Tang and radiation for the treatment of nasopharyngeal carcinoma can reduce the patients radiotherapy response and improve the survival rate without long-term toxicity.