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目的观察胃癌组织中基质金属蛋白酶2(mmp-2)的表达与侵袭程度和淋巴结转移的关系。方法应用免疫组化S-P法检测78例胃癌组织中mmp-2的表达。结果mmp-2表达强度与早期胃癌及进展期胃癌的病理分期显著相关(P<0.01),与淋巴结有无转移显著相关(P<0.01)。结论mmp-2表达强度与胃癌分期以及有无淋巴结转移有显著相关性,是判断胃癌分期和转移有价值的指标。
Objective To observe the relationship between the expression of matrix metalloproteinase 2 (MMP-2) and the degree of invasion and lymph node metastasis in gastric cancer. Methods The expression of mmp-2 in 78 cases of gastric carcinoma was detected by immunohistochemical S-P method. Results The expression level of mmp-2 was significantly correlated with the pathological stage of gastric cancer and advanced gastric cancer (P <0.01), but not with lymph node metastasis (P <0.01). Conclusions There is a significant correlation between the expression of mmp-2 and the staging of gastric cancer and the presence or absence of lymph node metastasis. It is a valuable index to judge the staging and metastasis of gastric cancer.