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目的：探讨小剂量三氯化钐（ Ｓｍ Ｃｌ３），三氯化镨（ Ｐｒ Ｃｌ３）对小鼠腹腔巨噬细胞（ Ｐ Ｍ ）形态结构及功能的影响。方法：选用雄性昆明小鼠，分别腹腔注射给予 ００５ ｍ ｇ·ｋｇ－ １，０５ ｍ ｇ·ｋｇ－ １ Ｓｍ Ｃｌ３和 Ｐｒ Ｃｌ３，连续７ ｄ。采用定量酶细胞化学、凝集素亲合细胞化学、透射电镜、扫描电镜及吞噬实验观察 Ｐ Ｍ 的结构和功能变化。结果：两种剂量 Ｓｍ Ｃｌ３ 、 Ｐｒ Ｃｌ３ 均使 Ｐ Ｍ 的酸性磷酸酶（ Ａ Ｃ Ｐ）、α醋酸萘酚酯酶（ Ａ Ｎ Ａ Ｅ）含量明显增加；刀豆蛋白 Ａ 受体（ Ｃｏｎ Ａ Ｒ）数目增多，吞噬中性红能力增强。电镜下 Ｐ Ｍ 胞质内溶酶体增多，表面皱褶及微绒毛增多。结论：小剂量 Ｓｍ Ｃｌ３、 Ｐｒ Ｃｌ３ 对小鼠 Ｐ Ｍ 的形态结构和功能有明显的促进作用。
Objective: To investigate the effects of small doses of SmCl3 and Pr Cl3 on the morphology and function of mouse peritoneal macrophages (PM). Methods: Male Kunming mice were selected and injected with 005 mg · kg-1, 1.05 mg · kg-1 SmCl3 and Pr Cl3 respectively for 7 consecutive days. The structure and function of P M were observed by quantitative enzyme cytochemistry, lectin affinity cytochemistry, transmission electron microscopy, scanning electron microscopy and phagocytosis. Results: Both SmCl3 and Pr Cl3 significantly increased the contents of acid phosphatase (P C) and α-Naphthol esterase (A N A E) in P M, Con A R) increased the number of phagocytic neutral red enhanced. Electron microscopy P M cytoplasmic lysosome increased surface folds and microvilli increased. Conclusion: Small doses of Sm Cl3 and Pr Cl3 can obviously promote the morphological structure and function of P M in mice.