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塌陷性肾小球病(collapsing glomerulopathy,CG)最初是在人类免疫缺陷病毒(human immunodeficiency virus,HIV)阳性患者中发现的一种特别的肾脏病,现在认为它与许多其他的疾病相关,比如系统性红斑狼疮(systemic lupus erythematosus,SLE)。SLE相关性CG(SLE-associated CG)是指在SLE患者中发现的一种罕见的临床病理实体,并除外其他引起CG的主要因素(比如HIV、细胞病毒B19、丙肝病毒、药物等),临床上以大量蛋白尿,对免疫抑制剂治疗反应差和急进性肾功能恶化为特点。本文对近年来国外有关SLE相关性CG的研究进展进行综述。
Collapsing glomerulopathy (CG) was originally a special kidney disease found in human immunodeficiency virus (HIV) positive patients and is now considered to be associated with many other diseases, such as systemic Systemic lupus erythematosus (SLE). SLE-associated CG (SLE-associated CG) refers to a rare clinical pathological entity found in SLE patients, with the exception of other major causes of CG (such as HIV, cytomegalovirus B19, hepatitis C virus, drugs, etc.) On a large number of proteinuria, poor response to immunosuppressive agents and acute renal dysfunction characterized. This review summarizes the research progress of CG related to SLE in foreign countries in recent years.