患者男性,51岁,因咳嗽,咳白痰伴双膝关节疼痛2个月,于1987年10月在某医院根据X线胸片拟诊为“右肺中叶癌”并行右肺中叶切除术。术后病理诊断:右肺中叶低分化腺癌,侵及纵隔及胸膜。同年10月29日转来我院,发现左锁骨上,双腹股沟均有淋巴结转移,宜行联合化疗。药物及总剂量为顺铂400mg,丝裂霉素36mg,氟脲嘧啶4g。化疗期间出现双膝盖疼痛,进行性加剧,跛行。髌骨压痛明显,无红肿及变形,行走困难。同年11月给予双膝关节正侧位片,示右膝关节及其形成骨均正常,未见破坏及增生征象,但左侧髌骨较透亮,骨小梁破坏,提示左髌骨转移瘤可能。经上述化疗后,第二次摄双膝关节正侧 The patient was a 51-year-old man with cough and cough with bilateral knee pain for 2 months. He was diagnosed as a “right middle lobe cancer” and right middle lobe resection in a hospital according to X-ray in October 1987. Postoperative pathological diagnosis: poorly differentiated adenocarcinoma of the right middle lobe, invading the mediastinum and pleura. October 29 the same year transferred to our hospital, found that the left clavicle, both inguinal lymph nodes metastasis, should be combined with chemotherapy. The total dose of the drug was cisplatin 400 mg, mitomycin 36 mg, and fluorouracil 4 g. Double knee pain occurs during chemotherapy and is progressively worsened. Painful cheekbones, no swelling and deformation, difficulty walking. In November of the same year, the bilateral knee joints were given lateral radiographs, showing that the right knee joint and its formation of bone were normal, no signs of destruction and proliferation, but the left temporal bone was more translucent, destruction of the trabecular bone, suggesting that the left metatarsal metastasis may be. After the above chemotherapy, the second side of the knee is taken for the second time.