现已明确霍乱腹泻的机理,乃是霍乱弧菌所产生的不耐热外毒素即霍乱肠毒素所致。当毒素与小肠上皮细胞膜上的特异受体结合,便使细胞中腺苷酸环化酶(AC)激活,促使细胞cAMP水平升高,导致细胞分泌功能亢进,引起大量水和电解质进入肠腔造成腹泻。已知产生肠毒素的常见病原菌, It is now clear that the mechanism of cholera diarrhea is caused by Vibrio cholerae endotoxin produced by heat-labile toxin that caused by cholera toxin. When the toxin binds to a specific receptor on the intestinal epithelial cell membrane, adenylate cyclase (AC) is activated in the cell and the level of cAMP is increased, resulting in hypersecretion of the cell and causing a large amount of water and electrolyte to enter the intestine diarrhea. Known to produce common toxins pathogens,