成人微小病变及轻度系膜增生性肾炎对糖皮质激素治疗反应好，有效率８０％左右［１］，但较易复发，需要反复使用大剂量糖皮质激素治疗。因而常出现激素的副作用，甚至影响疗程的完成。本文探讨大剂量甲泼尼龙冲击疗法治疗原发性肾病综合征（Ｐｒｉ－ｍａｒｙ　ｎｅｐｈｒｏｔ Small adult lesions and mild mesangial proliferative glomerular nephritis response to glucocorticoid treatment, the effective rate of about 80% [1], but easier to relapse, the need for repeated doses of glucocorticoid therapy. Thus often the side effects of hormones, and even affect the completion of treatment. This article discusses the high-dose methylprednisolone therapy for the treatment of primary nephrotic syndrome (Pri-mary nephrot