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原发性高血压的基础和临床研究强烈提示交感神经参与高血压发病机理,但其本质尚未阐明。我们在研究交感神经与高血压发病关系中,选择多巴胺—β—羟化酶(简称DBH)作为观察指标,主要考虑: (1)在儿茶酚胺生物合成中,DBH促使多巴胺β位羟化,而形成去甲肾上腺素。交感神经兴奋时,DBH与去甲肾上腺素通过细胞外溢方式,成比例同时从交感神经末稍释放。血浆(或血清)DBH活性可作为交感神经功能指标。
Essential and clinical studies of essential hypertension strongly suggest sympathetic involvement in the pathogenesis of hypertension, but its nature has not yet been elucidated. In the study of the relationship between sympathetic and hypertension, we chose dopamine-β-hydroxylase (DBH) as the observation index, the main consideration: (1) DBH in the catecholamine biosynthesis, β-hydroxylation of dopamine to form Norepinephrine. Sympathetic excitement, DBH and norepinephrine through the spillover manner, in proportion to the same time release from the sympathetic nerve. Plasma (or serum) DBH activity can be used as an index of sympathetic function.