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目的 研究t(4 ;1 1 )急性淋巴细胞白血病 (急淋 )的形态学、免疫学、细胞遗传学和临床特点。方法 1 0例t(4 ;1 1 )急淋 ,其中 8例为初诊患者 ,2例为急淋复发患者 ,经DOPL(柔红霉素、长春新碱、泼尼松、左旋门冬酰胺酶 )、VP(长春新碱、泼尼松 )等不同联合方案化疗。 7例采用流式细胞仪进行细胞免疫标记分析 ;所有病例采用骨髓细胞直接法或短期培养法制备染色体标本 (例 7为外周血培养 ) ,采用RHG显带技术进行核型分析。结果 t(4 ;1 1 )急淋占同期急淋的 3 .5%。 1 0例t(4 ;1 1 )急淋中 6例WBC >1 0 0× 1 0 9/L ,1 0例均有不同程度的肝、脾和淋巴结浸润。 5例为单纯t(4 ;1 1 ) ,5例同时出现其它的染色体异常。细胞免疫学表面标记除 1例为HLA DR和CD5 阳性外 ,6例CD19阳性 ,5例CD2 2阳性 ,支持绝大多数为B祖细胞急淋。本组急淋患者中位生存期为 5.5个月。结论 t(4 ;1 1 )急淋是一种预后不良的、独特的临床细胞遗传学亚型。
Objective To investigate the morphological, immunological, cytogenetic and clinical features of t (4; 1 1) acute lymphoblastic leukemia. Methods Totally 10 cases of t (4; 1 1) acute lymphocytic leukemia patients were included. Among them, 8 cases were newly diagnosed patients and 2 cases were treated with acute lymph node recurrence. DOPL (daunorubicin, vincristine, prednisone, ), VP (vincristine, prednisone) and other different combination chemotherapy. Seven cases were analyzed by flow cytometry for cellular immunolabeling. Chromosome specimens were prepared by direct or short-term culture of bone marrow cells (Example 7, peripheral blood culture), and karyotype analysis was performed by RHG banding technique. Results t (4; 1 1) acute shower accounted for 3.5% of the same period acute shower. 10 cases of t (4; 1 1) acute lymphoid WBC> 1 0 0 × 109 / L, 10 cases had varying degrees of liver, spleen and lymph node infiltration. 5 cases of simple t (4; 1 1), 5 cases of other chromosomal abnormalities occur at the same time. In addition to HLA-DR and CD5 positive in 1 immunocytological surface marker, 6 were positive for CD19 and 5 were positive for CD2 2, supporting the vast majority of acute lymphoblastic leukemia. The group of acute lymph node disease in patients with a median survival of 5.5 months. Conclusions t (4; 1 1) Acute lymphocytosis is a subtype of clinically distinct cytogenetics with poor prognosis.