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目的观察奥沙利铂(L-OHP)联合亚叶酸钙(CF)和大剂量5-Fu持续48 h滴注治疗中晚期结直肠癌的临床疗效和毒性。方法L-OHP 130 mg/m2,静脉滴注3 h,第1天;CF 200 mg/m2,静脉滴注,第1~5天,5-Fu 0.5 g,于CF滴注后静脉推注,第1天,接着用5-Fu 2.0 g/m2采用便携式输液泵持续输注48 h,21 d为1周期。结果共治疗31例中晚期结直肠癌,完全缓解(CR)2例,部分缓解(PR)14例,总有效率51.6%。主要毒副反应是消化道反应和神经毒性。结论奥沙利铂为主的联合化疗治疗中晚期结直肠癌的疗效较好,毒副反应轻,患者可以耐受。
Objective To observe the clinical efficacy and toxicity of oxaliplatin (L-OHP) combined with folinic acid (CF) and high-dose 5-Fu for 48 hours instillation for the treatment of advanced colorectal cancer. Methods L-OHP 130 mg / m2, intravenous infusion of 3 h, the first day; CF 200 mg / m2, intravenous drip, the first 5 days, 5-Fu 0.5 g, On the first day, a continuous infusion of 5-Fu 2.0 g / m2 was performed for 48 hours using a portable infusion pump, and the 21-day cycle was 1 week. Results A total of 31 patients with moderate to advanced colorectal cancer were treated. Two patients had complete remission (CR), 14 had partial remission (PR), and the total effective rate was 51.6%. The main side effects are gastrointestinal reactions and neurotoxicity. Conclusion The combination of oxaliplatin-based chemotherapy in the treatment of advanced colorectal cancer has good curative effect, mild side effects and tolerable patients.