目的　探讨急性有机磷农药中毒 (AOPI)病人心肌酶变化规律。方法　对 2 17例AOPI病人心肌酶 (AST、LDH、α -HBDH、CK、CK MB)进行连续监测 ,并观察病人心脏功能改变。结果　AOPI病人心肌酶均有不同程度升高 ,且与中毒程度呈正相关 ,心肌酶随病情改善呈恢复趋势。结论　心肌酶水平对AOPI病人具有预后作用 ,极度升高者 ,病情严重 ,预后不良。对重症病人应加强心脏监护 ,以防心源性猝死发生 Objective To investigate the changes of myocardial enzymes in patients with acute organophosphorus pesticide poisoning (AOPI). Methods The myocardial enzymes (AST, LDH, α-HBDH, CK, CK MB) in 21 AOPI patients were continuously monitored and their cardiac function was observed. Results The myocardial enzymes in AOPI patients all increased to some extent, and were positively correlated with the degree of poisoning. The myocardial enzymes recovered with the improvement of the disease. Conclusions Myocardial enzyme levels have a prognostic effect on patients with AOPI, with extremely elevated disease, severe illness and poor prognosis. In critically ill patients, cardiac monitoring should be strengthened to prevent sudden cardiac death