目的探讨三维适形放疗(3DCRT)联合肝动脉化疗栓塞(TACE)治疗原发性肝癌的综合治疗效果及不良反应。方法经病理学证实原发性肝癌36例,采用先行TACE,再行3DCRT,观察疗效及生存期。结果全组患者在治疗后疗效判定,局控率及治疗后3个月、6个月及1年生存率,CR4例(11.1%),PR26例(72.2%),NC3例(8.3%),PD3例(8.3%),总有效率(CR+PR)83.3%。主要的不良反应为消化道症状及骨髓抑制。结论三维适形放疗联合肝动脉化疗栓塞术是非手术治疗原发性肝癌的有效治疗方案。 Objective To investigate the combined treatment and side effects of three-dimensional conformal radiotherapy (3DCRT) and transcatheter arterial chemoembolization (TACE) in the treatment of primary liver cancer. Methods Totally 36 cases of primary liver cancer were confirmed by pathology. TACE was performed first and then 3DCRT was performed again to observe the curative effect and survival time. Results All the patients were evaluated after treatment, the rate of local control and the survival rates at 3 months, 6 months and 1 year after treatment, CR4 cases (11.1%), PR26 cases (72.2%), NC3 cases (8.3% PD3 cases (8.3%), the total effective rate (CR + PR) 83.3%. The main adverse reactions were gastrointestinal symptoms and myelosuppression. Conclusion Three-dimensional conformal radiotherapy combined with transcatheter arterial chemoembolization is an effective treatment for non-surgical treatment of primary liver cancer.