论文部分内容阅读
目的探讨精氨酸刺激试验(AST)和胰高血糖素刺激试验(GST)在糖尿病病人的年龄、病程和体重指数(BMI)等不同的情况下评价胰岛β细胞功能的价值,以指导临床合理评价胰岛β细胞功能。方法60例2型糖尿病(T2DM)患者分成A、B两组及不同亚组,采用自身对照及交叉试验方法,分别测定血糖、精氨酸(Arg)刺激后3min、胰高血糖素(Glg)刺激后6min的C肽释放水平并作比较。结果A、B两组注射Arg、Glg后血压、血糖均无明显升高(P>0.05),各组比较精氨酸刺激后3minC肽与胰高血糖素刺激后6minC肽差异均无统计学意义(P>0.05),且存在正相关(P均<0.05)。结论AST、GST相对于口服糖耐量试验对DM患者是有利的;胰岛β细胞对Arg和Glg这两种非葡萄糖刺激物的反应程度相似,而且两试验结果的相关性良好,对临床合理选用评价胰岛β细胞功能的方法有一定的参考价值。
Objective To investigate the value of AST and GST in evaluating the function of pancreatic β-cells in diabetic patients under different circumstances, such as age, duration of disease and body mass index (BMI), so as to guide clinical reasonable Evaluation of pancreatic β-cell function. Methods Sixty patients with type 2 diabetes mellitus (T2DM) were divided into two groups (A and B) and subgroups. The levels of glucose, arginine (Arg) 3min, glucagon (Glg) C-peptide release levels 6 min after stimulation and comparison. Results The blood pressure and blood glucose of A and B groups were not significantly increased after Arg and Glg injection (P> 0.05). There was no significant difference in peptide between 6 min and 6 min after stimulated by arginine (P> 0.05), and there was a positive correlation (all P <0.05). Conclusion AST and GST are superior to oral glucose tolerance test in DM patients. The response of islet β cells to Arg and Glg are similar to those of non-glucose stimulants, and the correlation between the two test results is good. The evaluation of clinical rational selection Islet β-cell function of the method has some reference value.