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目的探讨不同的血液灌流方法抢救重度有机磷中毒的临床疗效,从中选出最优化的血液灌流方法。方法对2012年3月至2012年9月在我院抢救的急性重度有机磷中毒病例148例经血液灌流治疗的患者,采用不同的血液灌流方法。两组均给予积极的常规治疗。前组采用200g碳肾吸附罐、90~100min灌流时间为优化组。后组采用150g碳肾吸附罐、120min以上灌流时间为常规组。结果两组胆碱酯酶恢复活性时间,并发症,抢救成功率,平均住院时间有显着差异(P<0.05)。结论优化血液灌流能更快速恢复重度有机磷中毒患者胆碱酯酶活性、减少并发症、提高抢救成功率并缩短住院时间。
Objective To investigate the clinical efficacy of different hemoperfusion methods in the treatment of severe organophosphorus poisoning and select the optimal hemoperfusion method. Methods A total of 148 patients with acute severe organophosphate poisoning who were treated in our hospital from March 2012 to September 2012 were treated with hemoperfusion. Different hemoperfusion methods were used. Both groups were given active routine treatment. The former group used 200g carbon renal adsorption cans, 90 ~ 100min perfusion time for the optimization group. The latter group used 150g carbon renal adsorption cans, 120min perfusion time for the conventional group. Results The cholinesterase recovery time, complications, rescue success rate and average length of stay in both groups were significantly different (P <0.05). Conclusion Optimized hemoperfusion can recover cholinesterase activity, reduce complications, improve rescue success rate and shorten hospital stay more quickly in patients with severe organophosphate poisoning.