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随着分子化学及基因工程学的进步,已证实病毒癌基因和原癌基因.目前在染色体上能定位的原癌基因达20多种,当今的研究方向为原癌基因转化发生癌的过程.近年各种癌细胞染色体特异性改变的报道不断增加.例如90%的慢性骨髓性白血病患者存在Ph~1染色体,所谓Ph~1染色体即22号染色体含有proto-abl基因部分易位到9号染色体.又例如骨髓瘤病人的8号染色体myc基因易位到14号染色体上等特异性染色体改变.如上所述,各类癌瘤具有各自相同的染色体易位的部位和一致的原癌基因位点的报道引起人们的关注.作者整理目前与妇癌有关特异性染色体异常的文献综述如下.
With the advancement of molecular chemistry and genetic engineering, the oncogenes and proto-oncogenes have been confirmed, and there are more than 20 proto-oncogenes located on the chromosomes. The current research direction is the carcinogenesis of proto-oncogenes. In recent years, there have been increasing reports of chromosome-specific changes in various cancer cells, for example, 90% of patients with chronic myeloid leukemia have Ph ~ 1 chromosomes, and the so-called Ph ~ 1 chromosome, chromosome 22, contains part of the proto-abl gene translocated to chromosome 9 In another example, the myc gene of myeloma patient translocates to a chromosome-specific chromosomal alteration on chromosome 14. As described above, each type of cancer has its own site of identical chromosomal translocations and a consensus oncogene site The report attracted the attention of the author finishing the current literature related to women with specific chromosomal abnormalities are summarized below.