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目的观察橄榄解酒饮对大鼠急性酒精性肝损伤的干预效果,探讨其对肝细胞凋亡进程的调节作用。方法采用白酒灌胃造模法,每天连续两次灌胃白酒,每次间隔1h,连续5d后取肝组织切片,检测凋亡细胞指数和Bcl-2蛋白,并与护肝胶囊对照。结果橄榄解酒饮可显著降低凋亡指数、增加Bcl-2蛋白阳性表达,与对照组比较差异有统计学意义(P<0.05)。结论橄榄解酒饮通过抑制肝细胞凋亡而减轻肝组织损伤。
Objective To observe the intervention effect of Ganlan Jiejiu Decoction on acute alcoholic liver injury in rats and explore its regulation effect on the progress of hepatocyte apoptosis. Methods Liquor gavage was used to establish the model. Two times a day, intragastrically, white liquor was given twice a day for 1 hour. After 5 days, liver tissue sections were taken for detection of apoptotic cell index and Bcl-2 protein, and compared with Hugan capsule. Results Ganlan Jiejiu Decoction significantly decreased the apoptotic index and increased the positive expression of Bcl-2 protein, which was significantly different from that of the control group (P<0.05). Conclusion Gandijieyin relieves hepatic tissue injury by inhibiting hepatocyte apoptosis.