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本工作以钾离子透入引起大鼠甩尾为痛指标，观察了内源性阿片肽与ＳＳ镇痛及加强电针镇痛作用的关系。侧脑室注射纳洛酮可部分阻断 ＳＳ的镇痛和增强电针镇痛的效应，说明 ＳＳ的镇痛和增强电针镇痛的作用可能与内源性阿片肽有关。侧脑室分别给予抗β－内啡肽血清（ＡＥＰＳ）、抗亮－脑啡肽血清（ ＡＬＥＫＳ）和抗强啡肽血清（ ＡＤＹＮＳ），观察到 ＡＥＰＳ和 ＡＬＥＫＳ可减弱ＳＳ的镇痛和增强电针镇痛的效应，其中 ＡＥＰＳ减弱 ＳＳ的镇痛作用较强， ＡＬＥＫＳ减弱 ＳＳ增强电针镇痛的作用较强，而 ＡＤＹＮＳ无论对 ＳＳ的镇痛作用还是增强电针镇痛的作用均无影响。以上结果表明 ＳＳ的镇痛和增强电针镇痛的作用与β－内啡肽和脑啡肽有关，而与强啡肽关系不大。
In this work, potassium drift into rats induced tail flick pain indicators, observation of endogenous opioid peptide and analgesic SS analgesic effect. Intracerebroventricular injection of naloxone can partially block the analgesic effect of SS and enhance the effect of electroacupuncture analgesia, indicating that the analgesic effect of SS and enhanced electroacupuncture analgesia may be related to endogenous opioid peptide. Anti-β-endorphin serum (AEPS), anti-enkephalin serum (ALEKS) and anti-dynorphin serum (ADYNS) were given to the lateral ventricle respectively. AEPS and ALEKS were observed to attenuate SS analgesia and enhance electroacupuncture The analgesic effects of AEPS were weakened by AEPS. ALEKS attenuated the effect of SS on enhancing electroacupuncture analgesia. However, ADYNS had no effect on the analgesic effects of SS or EA. The above results show that the analgesic effect of SS and enhance the role of electroacupuncture analgesia with β-endorphin and enkephalin, but not with the dynorphin peptide.