目的： 探讨应用呼吸机和大剂量氯磷定突击疗法对经口有机磷中毒并发中间型综合征（ｉｎｔｅｒｍｅｄｉａｔｅｓｙｎｄｒｏｍｅ ，ＩＭＳ） 所致后期呼吸衰竭的疗效。方法： 回顾性分析３２ 例患者的临床表现、血清胆碱酯酶（ｃｈｏｌｉｎｅｓｔｅｒａｓｅ ，ＣＨＥ） 活力、血气指标和存活率。结果：３２ 例患者经一般治疗无效，很快全部出现胆碱能危象、血清胆碱脂酶活力下降、肌无力和呼吸衰竭，应用呼吸机和大剂量氯磷定突击疗法，完全治愈３０ 例，治愈率９３７５ ％ ，死亡２ 例，占６２５ ％ 。结论： 有机磷中毒合并ＩＭＳ 致后期呼吸衰竭的患者应用呼吸机和大剂量氯磷定突击疗法能显著改善患者的预后，降低死亡率 Objective: To investigate the effect of respirator and high-dose oxychloride-induced assault therapy on late respiratory failure caused by oral organophosphate poisoning complicated by intermediate syndrome (IMS). Methods: A retrospective analysis of 32 patients with clinical manifestations, serum cholinesterase (CHE) activity, blood gas indicators and survival rate. Results: 32 patients were ineffective in general treatment, and soon all appeared cholinergic crisis, serum cholinesterase activity decreased, muscle weakness and respiratory failure, the use of ventilator and high-dose of chlorpromazine assault therapy, completely cured in 30 cases , The cure rate was 9375%, 2 died, accounting for 625%. Conclusion: Patients with organophosphate poisoning combined with IMS-induced late respiratory failure can significantly improve prognosis and reduce mortality in patients treated with ventilator and high-dose chlorpromazine