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为证实产生硫酸软骨素酶的厌氧菌是引致大骨节病的主要因素进行了实验研究。从山东省益都(青州市)和陕西省永寿病区分离出产酶菌。将该菌制成菌粮饲养小白鼠30d后,有84.61%(11/13)的小白鼠关节软骨组织出现类似人类大骨节病的病理学改变。对大骨节病的4个特点,3种病因假说以及改水、改善卫生可以降低发病率等作了讨论。提出产生硫酸软骨素酶厌氧菌引致大骨节病的新假说。
In order to confirm that the anaerobic bacteria producing chondroitinase are the major factors leading to Kashin-Beck disease, an experimental study was conducted. Isolation of enzyme-producing bacteria from Yidu (Qingzhou), Shandong province and Yongshou ward, Shaanxi province. After the bacteria were made into bacteria-fed mice for 30 days, 84.61% (11/13) of mouse articular cartilage tissues showed pathological changes similar to human Kaschin-Beck disease. Four characteristics of Kashin-Beck disease, three etiological hypotheses, as well as water improvement and health improvement, were discussed. A new hypothesis of Kashin-Beck disease caused by chondroitinase-producing anaerobic bacteria was proposed.