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目的探讨克罗米芬(CC)联合人绝经期促性腺激素(HMG)对妊娠结局和子宫内膜厚度的影响。方法选取我院2010年1月-2012年8月不孕不育患者154例,随机分为两组各77例,观察组给予CC+HMG,对照组单纯给予CC,观察两组排卵率、妊娠率、流产率及子宫内膜厚度、类型和血流参数S/D值的影响。结果观察组患者的排卵率和妊娠率分别为92.21%和31.37%,显著高于对照组,差异有统计学意义(P<0.05),两组流产率无统计学差异(P>0.05)。观察组子宫内膜血流S/D小于对照组,而自子宫内膜厚度大于对照组,差异有统计学意义(P<0.05),两组子宫内膜类型无统计学差异(P>0.05)。结论克罗米芬联合人绝经期促性腺激素可显著提高患者排卵率和妊娠率,改善子宫内膜血流灌注和子宫内膜厚度,为一项促排卵治疗的有效措施。
Objective To investigate the effect of clomiphene citrate combined with menopausal gonadotrophin (HMG) on pregnancy outcome and endometrial thickness. Methods A total of 154 inpatients with infertility were selected from January 2010 to August 2012 in our hospital. They were randomly divided into two groups of 77 cases. CC + HMG was given to the observation group and CC was given to the control group. The ovulation rate, pregnancy rate Rate, abortion rate and endometrial thickness, type and blood flow parameters S / D values. Results The ovulation rate and pregnancy rate in the observation group were 92.21% and 31.37%, respectively, which were significantly higher than those in the control group (P <0.05). There was no significant difference in abortion rate between the two groups (P> 0.05). The endometrial blood flow S / D in the observation group was smaller than that in the control group, but the thickness of the endometrium was higher than that in the control group (P <0.05). There was no significant difference in the endometrial types between the two groups (P> 0.05) . Conclusion Clomiphene combined with human menopausal gonadotropin can significantly improve the ovulation rate and pregnancy rate of patients, improve endometrial blood flow and endometrial thickness, is an effective treatment for ovulation induction.