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[目的]探讨冠心病患者介入诊疗后造影剂肾病(CIN)发生的相关危险因素。[方法]选择360例接受PCI治疗的冠心病患者为研究对象,根据患者术后48h内的血清肌酐水平变化分为CIN组和非CIN组,并对相关危险因素进行分析。[结果]术后造影剂肾病组年龄≥70岁、术前血清肌酐(SCr)≥1.5mg/L、心功能≥3级、术中造影剂用量过大、围手术期未进行水化治疗明显高于肾功能正常组(P﹤0.05)。应用Logistic回归分析发现术后发生造影剂肾病的危险因素为年龄≥70岁、术前血清肌酐≥1.5mg/L、心功能≥3级、术中造影剂用量过大、围手术期未进行水化治疗(P﹤0.05,OR﹥1)。[结论]肾功能不全、糖尿病、造影剂剂量及高龄是PCI术后造影剂肾病发生的危险因素。
[Objective] To explore the related risk factors of contrast-induced nephropathy (CIN) after interventional therapy in patients with coronary heart disease. [Methods] A total of 360 CHD patients undergoing PCI were enrolled in this study. CIN group and non-CIN group were divided according to changes of serum creatinine level within 48 hours after operation, and the related risk factors were analyzed. [Results] The postoperative contrast nephropathy group was ≥70 years old, preoperative serum creatinine (SCr) ≥1.5mg / L, cardiac function≥3 grade, the dosage of contrast medium was too large and the perioperative hydration therapy was not obvious Higher than the normal renal function group (P <0.05). Logistic regression analysis found that the risk factors of contrast-induced nephropathy were age≥70 years, preoperative serum creatinine≥1.5mg / L, cardiac function≥3, the amount of intra-operative contrast agent was too large, no perioperative water Treatment (P <0.05, OR> 1). [Conclusion] Renal insufficiency, diabetes mellitus, contrast agent dosage and advanced age are the risk factors of contrast agent nephropathy after PCI.