老年人髋部骨折与发病率、死亡率增加和功能障碍相关。入院接受髋部骨折手术修复的患者(n=2127)随机接受每年一次唑来磷酸静脉注射或安慰剂加维生素D及钙剂治疗。主要临床终点是新发临床骨折的诊断。唑来磷酸组新发临床骨折的几率为8.6%,而在安慰剂组为13.9%,减少骨折风险35%(P=0.001),唑来 Hip fractures in the elderly are associated with increased morbidity, increased mortality, and dysfunction. Patients admitted to hospital for hip fracture surgeries (n = 2127) were randomized to receive azolephosphate once a year or placebo plus vitamin D and calcium. The primary clinical endpoint is the diagnosis of a new clinical fracture. The odds of a new clinical fracture in the zoledronic acid group were 8.6%, compared with 13.9% in the placebo group, a 35% reduction in the risk of fracture (P = 0.001)