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目的研究赛庚啶对大鼠垂体－甲状腺轴内分泌功能的影响。方法用放射免疫分析法和电镜观察赛庚啶对大鼠垂体－甲状腺轴内分泌功能及垂体ＴＳＨ细胞超微结构的影响。结果赛庚啶２．３ｍｇ·ｋｇ－１，ｉｇ，连续用药１０ｄ，可使大鼠血清促甲状腺激素（ＴＳＨ）含量明显降低（Ｐ＜０．０５），而甲状腺激素（Ｔ３，Ｔ４）则无显著变化。４．６ｍｇ·ｋｇ－１赛庚啶可引起大鼠血清ＴＳＨ，Ｔ３，Ｔ４水平均显著降低（Ｐ＜０．０１及０．０５），组织形态电镜观察，该药亦引起大鼠垂体ＴＳＨ细胞超微结构的退行性改变。结论赛庚啶对大鼠垂体－甲状腺轴的内分泌功能有抑制作用。
Objective To study the effect of cyproheptadine on endocrine function of pituitary-thyroid axis in rats. Methods The effects of cyproheptadine on the endocrine function of pituitary - thyroid axis and the ultrastructure of pituitary TSH in rats were observed by radioimmunoassay and electron microscope. Results Cyclopine (2.3 mg · kg -1, ig, continuous administration for 10 days) significantly decreased serum thyrotropin (TSH) levels in rats (P <0.05), while thyroid hormone (T3, T4) Significant changes. 4.6mg · kg-1 cyproheptadine can cause serum TSH, T3, T4 levels were significantly lower (P <0.01 and 0.05), the morphology of electron microscopy, the drug also caused rat pituitary TSH cells Degenerative changes in ultrastructure. Conclusion Cyproheptadine can inhibit the endocrine function of rat pituitary - thyroid axis.