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目的对我院Rh D阴性孕妇IgG抗-D筛查与效价检测的意义进行分析。方法采集1 397例Rh D阴性孕妇的血清,作血型抗体筛查与特异性鉴定,并对抗体阳性患者作效价检测,并追踪抗体阳性患者的新生儿状态。结果在1 397例Rh D阴性孕妇血清中,IgG抗-D阳性146例,阳性率为10.45%(146/1 397),观察146例孕妇IgG抗-D与Rh-HDN发病率的相关性。结论 Rh D阴性孕妇IgG抗-D筛查与效价测定,发现抗体效价16为Rh-HDN发生的临界值,对于Rh血型不合新生儿溶血病的预测、治疗具有重要价值。
Objective To analyze the significance of IgG anti-D screening and titer detection of Rh D-negative pregnant women in our hospital. Methods The serum of 1 397 Rh D-negative pregnant women was collected for screening and specific detection of blood group antibody. The antibody titer was tested in patients with positive antibody and the neonatal status was tracked in patients with positive antibody. Results In the serum of 1 397 Rh D-negative pregnant women, IgG anti-D was positive in 146 cases and the positive rate was 10.45% (146/1 397). The correlation between IgG anti-D in 146 pregnant women and the incidence of Rh-HDN was observed. Conclusion Anti-D screening and titer determination of IgG in Rh-negative pregnant women shows that antibody titer 16 is the critical value of Rh-HDN, which is of great value for the prediction and treatment of Rh-type incompatible neonatal hemolytic disease.