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目的针对鼻咽癌放射治疗后的粘膜反应,采用维生素B_(12)雾化吸入,进行临床观察对放射性粘膜损伤的作用。方法采用从2011年5月至2014年5月在我院接受放疗的均经病理证实的100例鼻咽癌患者。其中50例使用超声雾化器行维生素B_(12)液雾化吸入治疗,50例对照组行生理盐水漱口进行疗效对照。结果维生素B_(12)雾化吸入组口腔粘膜严重放射损伤(Ⅲ度放射反应)的比例低于对照组(P<0.01),而发生Ⅱ度和Ⅲ度放射损伤的耐受量高于对照组(P<0.05)。结论通过两组对照观察,维生素B_(12)雾化吸入可以减轻鼻咽癌放射治疗后粘膜反应,是防止和减轻放射性粘膜损伤的有效方法之一。
Objective To study the mucosal response of nasopharyngeal carcinoma after radiotherapy, and to observe the effect of clinical observation on radiation mucosal injury by inhalation of vitamin B_ (12). Methods From May 2011 to May 2014 in our hospital were treated with radiotherapy were pathologically confirmed 100 cases of nasopharyngeal carcinoma patients. Among them, 50 cases were treated with vitamin B_ (12) liquid atomization inhalation by ultrasonic nebulizer, and 50 cases were given saline control gargle. Results Compared with the control group (P <0.01), the ratio of severe radiation injury (Ⅲ degree radiotherapy) to inhaled vitamin B 12 in oral inhalation group was significantly lower than that in control group (P <0.01) (P <0.05). Conclusion Through the two groups of controlled observation, vitamin B 12 inhalation can reduce the mucosal reaction of nasopharyngeal carcinoma after radiotherapy, which is one of the effective ways to prevent and reduce the radiation mucosal injury.