目的探讨和总结急性出血坏死性胰腺的手术和5-FU的临床疗效。方法对近10年来我院收治的3例急性出血坏死性胰腺炎的病史资料进行回顾性总结和分析,评价手术和并用5-FU的疗效。结果 3例均及时果断进行了剖腹探查,清除病灶,通畅引流,积极规范使用5-FU治疗,疗效均满意,无一例死亡。结论该病多有诱因,发病急,病情发展快,死亡率高,并发症多。及时手术和使用5-FU治疗,是一易行的治疗手段,值得总结和推广。 Objective To investigate and summarize the clinical efficacy of surgery and 5-FU for acute hemorrhagic and necrotic pancreas. Methods The clinical data of 3 cases of acute hemorrhagic necrotizing pancreatitis admitted to our hospital in the past 10 years were retrospectively reviewed and analyzed to evaluate the efficacy of 5-FU combined with surgery. Results All the 3 cases were timely and exploratory laparotomy, and the lesions were cleared. The 5-FU regimen was actively and normaly used. All patients were satisfied with the results and none died. Conclusion There are many causes of the disease, acute onset, rapid progression, high mortality and complications. Timely surgery and the use of 5-FU treatment, is an easy treatment, it is worth summarizing and promotion.