唐氏综合征 (DS)患者体内存在异常的氧化应激 ,2 1号染色体上Cu Zn超氧化物歧化酶的基因 (2 1q2 2 .1 )过度表达是引起DS患者发生氧化应激增高的关键因素。由于Cu Zn超氧化物歧化酶的过度表达 ,导致体内氧化与抗氧化酶系统失衡 ,从而引起反应性氧族活性增高 ,慢性氧化应激、过氧化反应增强 ,细胞退行性变及凋亡。目前对DS还没有有效的治疗方法。体外试验已经证明自由基清除剂及过氧化氢酶可以完全预防DS胎儿脑皮质神经元的退行性变 ,但将它们应用于临床尚在研究中 Abnormal oxidative stress is present in patients with Down Syndrome (DS). Overexpression of Cu Zn superoxide dismutase gene (2 1q2 2 .1) on chromosome 21 is the key factor in the increased oxidative stress in DS patients factor. Overexpression of Cu Zn superoxide dismutase results in imbalance of oxidation and antioxidant enzyme system in vivo, resulting in increased reactive oxygen species activity, chronic oxidative stress, increased peroxidation, degeneration of cells and apoptosis. There is currently no effective treatment for DS. In vitro tests have shown that free radical scavengers and catalases can completely prevent the degeneration of DS fetal cortical neurons, but they are still being used in clinical studies