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目的探讨发热伴血小板减少综合征(Severe Fever with Thrombocytopenia Syndrome,SFTS)流行病学及临床特征。方法采用统一的诊断标准和流行病学个案调查表对病例进行调查。结果 2011-2014年威海市立医院共报告101例确诊病例,死亡8例,病死率7.92%。病例年龄中位数为62岁(范围为33~82岁),男女性别比为0.87(47∶54);农民占全部病例的74.25%(75/101);病例主要集中在6-8月份,占74.25%(75/101);9.90%(10/101)病例有明确蜱虫叮咬史,3.96%(4/101)病例与患者有密切接触史。临床表现主要有发热(100%)、乏力(77.52%)、精神不振(51.69%)、恶心(47.19%)、腹泻(41.57%)等症状;实验室检查WBC、PLT降低,ALT、AST、LDH、CK、肌酸激酶同工酶、a-羟丁酸脱氢酶升高。结论病例多发生在夏季,呈散在发生,以中老年为主,职业以农民为主。临床表现以发热伴白细胞、血小板减少和多脏器功能损害为主。60岁以上病例病情较重。
Objective To investigate the epidemiology and clinical features of Severe Fever with Thrombocytopenia Syndrome (SFTS). Methods Uniform diagnostic criteria and epidemiological case questionnaires were used to investigate the cases. Results From 2011 to 2014, Weihai Municipal Hospital reported a total of 101 confirmed cases, with 8 deaths and a mortality rate of 7.92%. The median age of patients was 62 years (range, 33-82 years), and the sex ratio was 0.87 (47:54). Farmers accounted for 74.25% (75/101) of all cases. The cases were mainly in June-August, Accounting for 74.25% (75/101); 9.90% (10/101) had a clear history of tick bites and 3.96% (4/101) had close contact with patients. The main clinical manifestations were fever (100%), fatigue (77.52%), sluggishness (51.69%), nausea (47.19%) and diarrhea (41.57%). The WBC, PLT, ALT, AST, , CK, creatine kinase isoenzyme, a-hydroxybutyrate dehydrogenase increased. Conclusions Cases occurred in the summer, occurred in scattered, mainly in the elderly, occupation dominated by peasants. Clinical manifestations of fever with leukocytes, thrombocytopenia and multiple organ dysfunction based. More than 60 years of age in serious condition.