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·AIM:To study the effect of theminocycline (MNC) on expression of bcl-2,bax in retinal nerve cells of rat with diabetes.·METHODS:Male SD rats were randomly divided into negative control group,model control group and MNC treated group.Diabetes model was established by intraperitoneal injection of 60mg/kg streptozotocin (STZ).The protein expressions of bcl-2 and bax in retina were detected by immunohistochemistry method.·RESULTS:Compared with the negative control group,bax immunoreactive neurons in retina were increased significantly (P<0.01) in model control group.However,bax immun-oreactive neurons in retina in MNC treated group were significantly decreased (P<0.01).Compared with the model control group,bcl-2 immunoreactive neurons in retina were increased significantly(P<0.01) in MNC treated group.·CONCLUSION:MNC can obviously decreased expression of bax and increased expression of bcl-2 in retina with DR.It is one of path of inhibiting impairment on retinal nerve cells with DR.·
· AIM: To study the effect of the minocycline (MNC) on expression of bcl-2, bax in retinal nerve cells of rat with diabetes. · METHODS: Male SD rats were randomly divided into negative control group, model control group and MNC treated group . Diabetes model was established by intraperitoneal injection of 60 mg / kg streptozotocin (STZ). The protein expressions of bcl-2 and bax in retina were detected by immunohistochemistry method. RESULTS: Compared with the negative control group, bax immunoreactive neurons in retina were increased significantly (P <0.01) in model control group. However, bax immun-oreactive neurons in retina in MNC treated group were significantly decreased (P <0.01) .Compared with the model control group, bcl-2 immunoreactive neurons in retina were increased significantly (P <0.01) in MNC treated group. · CONCLUSION: MNC can obviously decreased expression of bax and increased expression of bcl-2 in retina with DR.It is one of the path of inhibiting impairment on retinal nerve cells with DR. ·