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目的研究肝舒胶囊对大鼠慢性肝损伤的保护作用。方法采用sc CCl4致大鼠慢性肝损伤,比色法测定血清中的ALT、AST、ALP、TP、ALB的含量,碱水解法测定肝组织中羟脯氨酸(HYP)的含量,并根据肝脏的脂变、炎症、水肿、细胞坏死、纤维组织增生观察病理组织学的形态变化。结果肝舒胶囊对血清中生化指标有一定的降低趋势,可明显降低血清中ALP和肝组织中的HYP;可明显改善肝组织的病理学变化。结论肝舒胶囊对慢性肝损伤有一定的保护作用。
Objective To study the protective effect of Ganshu Capsule on chronic liver injury in rats. Methods Chronic liver injury was induced by scCCl4 in rats. Colorimetric method was used to determine serum ALT, AST, ALP, TP and ALB levels. Alkaline hydrolysis was used to determine hydroxyproline (HYP) content in liver tissue. The morphological changes of histopathology were observed by lipolysis, inflammation, edema, cell necrosis, and fibrous tissue hyperplasia. RESULTS: Ganshu capsules had a certain decrease trend in serum biochemical indicators, which could significantly reduce serum ALP and HYP in liver tissue; it could significantly improve the pathological changes of liver tissue. Conclusion Ganshu Capsule has a certain protective effect on chronic liver injury.