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介绍了L 缬氨酸经消旋化及化学拆分制备D 缬氨酸的方法 .苯甲酰氯和D 酒石酸反应生成D 2 ,3 二苯甲酰酒石酸酐 ,后者于丙酮水溶液中水解得到拆分剂D 2 ,3 二苯甲酰酒石酸 .在醛的催化下 ,L 缬氨酸于 10 0～ 110 ℃ 消旋化 3h得到DL 缬氨酸 .DL 缬氨酸在无机酸存在下与D 2 ,3 二苯甲酰酒石酸于 84～ 95 ℃ 反应生成非对映体盐 .当温度降低至 15 ℃ ,D 2 ,3 二苯甲酰酒石酸和D 缬氨酸形成的盐沉淀出来 ,用碱处理该盐后得到D 缬氨酸 ,收率为 70 %～ 80 % ,光学纯度达到 98%以上 .
A method for preparing D-valine by racemization and chemical resolution of L-valine is described. Benzoyl chloride and D-tartaric acid are reacted to form D 2, 3 dibenzoyl tartaric anhydride, which is hydrolyzed in an acetone aqueous solution to obtain a D 2, 3 dibenzoyltartaric acid. Under the catalysis of aldehyde, L-valine is racemized at 10 0 ~ 110 ℃ for 3h to obtain DL valine DL-valine is reacted with D 2 , 3 dibenzoyltartaric acid reacts at 84-95 ° C to form diastereomeric salts.When the temperature is lowered to 15 ° C, salts of D 2, 3 dibenzoyltartaric acid and D-valine are precipitated and treated with base After the salt, D-valine is obtained in a yield of 70% -80% and an optical purity of more than 98%.