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目的:探讨内皮素-1(ET-1)、一氧化氮(NO)在大鼠肝硬化合并肝肾综合征(HPS)发病机制中的作用。方法:40只雄性Wistar大鼠随机分成4组,每组10只,采用胆总管结扎(CBDL)术制备大鼠HPS模型,模型制备成功后,抽取静脉血行肝功能及肝病理检查,榆测血浆和肾组织ET的浓度以及血清和肾组织NO的浓度。结果:测得试验组血浆和肾组织ET的浓度以及血清和肾组织NO的浓度与对照组相比差剧有显著性(P<0.05)。结论:(1)试验组ET和NO的水平明显高于对照组,可作为肝肾综合征的早期诊断标准。(2)为临床上预防及治疗肝肾综合征提供1新思路。
Objective: To investigate the role of endothelin-1 (ET-1) and nitric oxide (NO) in the pathogenesis of cirrhosis and hepatorenal syndrome (HPS) in rats. Methods: Forty male Wistar rats were randomly divided into 4 groups (n = 10 each). HPS model was induced by common bile duct ligation (CBDL). After the model was successfully established, the liver function and liver pathology were extracted. And the concentration of ET in kidney tissue and the concentration of NO in serum and kidney tissue. Results: The concentration of plasma ET and ET and the concentration of NO in serum and kidney were significantly lower than those in the control group (P <0.05). Conclusion: (1) ET and NO levels in the experimental group were significantly higher than those in the control group, which could be used as an early diagnostic criteria for hepatorenal syndrome. (2) To provide a new idea for clinical prevention and treatment of hepatorenal syndrome.