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目的 :研究 β-葡萄糖醛酸苷酶与人大肠癌分化、侵袭和转移间的关系。 方法 :链酶卵白素 -过氧化物酶免疫组化法检测 β -葡萄糖醛酸苷酶在大肠癌组织中的表达。结果 :β -葡萄糖醛酸苷酶的增强表达与大肠癌Dukes分期的进展相关 (P <0 .0 5 ) ,随着侵袭深度的加深 ,癌组织中 β -葡萄糖醛酸苷酶的表达增强 (P <0 .0 5 )。该酶在低分化大肠癌中的表达强于高分化大肠癌 ,但无统计学意义。结论 :β -葡萄糖醛酸苷酶的表达与大肠癌的侵袭力成正相关 ,其免疫组化染色可能成为诊断大肠癌侵袭力的有用指标。
Objective: To study the relationship between β-glucuronidase and the differentiation, invasion and metastasis of colorectal cancer. Methods: The expression of β-glucuronidase in colorectal cancer tissues was detected by streptavidin-peroxidase immunohistochemistry. Results: The enhanced expression of β-glucuronidase was associated with the progression of Dukes staging of colorectal cancer (P < 0.05). With the deepening of the invasion depth, the expression of β-glucuronidase in cancer tissues was enhanced ( P <0. 0 5 ). The expression of this enzyme in poorly differentiated colorectal cancer was stronger than that in well-differentiated colorectal cancer, but it was not statistically significant. Conclusion : The expression of β-glucuronidase is positively correlated with the invasiveness of colorectal cancer, and its immunohistochemical staining may be a useful indicator for the diagnosis of invasiveness of colorectal cancer.