用放射免疫法检测６５５例各种肝病病人，２３５例非肝病病人及４２名正常对照者的血清Ⅲ型前胶原（ＰＣⅢ）、透明质酸（ＨＡ）及层粘连蛋白（ＬＮ）水平及部分肝功能变化。结果表明ＣＡＨ，ＬＣ患者血清ＰＣⅢ、ＨＡ、ＬＮ水平均显著高于ＮＣ、ＮＬ、ＣＰＨ及ＡＨ患者；而ＮＬ，ＣＰＨ与ＮＣ比较无差异，三项指标与肝硬化ｃｈｉｌｄ－ｐｕｇｈ分级无明显相关。此外血清ＬＮ与门脉压力程度有相关性。提示ＰＣⅢ，ＨＡ、ＬＮ血清学测定对肝纤维化及早期肝硬化的诊断有重要价值。 Radioimmunoassay was used to detect the levels of PCⅢ, HA and LN in 655 patients with liver disease, 235 patients with non-liver disease and 42 healthy controls, Function changes. The results showed that the serum levels of PCⅢ, HA and LN in patients with CAH and LC were significantly higher than those in patients with NC, NL, CPH and AH. There was no difference between NL, CPH and NC. There was no significant correlation between the three indexes and the level of child-pugh cirrhosis. In addition, serum LN and portal pressure have a correlation. Tip PCⅢ, HA, LN serological determination of liver fibrosis and early diagnosis of cirrhosis of great value.