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[目的]探讨妊娠肝内胆汁淤积症(ICP)高危因素,为ICP的临床治疗提供理论依据。[方法]选择2009年1月~2010年12月某院住院分娩ICP患者82例(ICP组)和正常晚期妊娠妇女86例(对照组)为研究对象,应用回归性对照研究对ICP高危因素进行分析。[结果]与对照组相比较,体内雌激素水平、机体免疫失调、遗传因素、微量元素硒的含量与ICP显著相关,差异有统计学意义(P﹤0.05)。多因素回归分析结果显示体内雌激素水平、机体免疫失调、微量元素硒的含量为ICP高危因素。[结论]体内雌激素水平、机体免疫失调、微量元素硒的含量为ICP高危因素,对有ICP的产妇积极采取措施,避免产后母儿并发症的发生。
[Objective] To investigate the risk factors of intrahepatic cholestasis of pregnancy (ICP) and provide a theoretical basis for the clinical treatment of ICP. [Methods] From January 2009 to December 2010, 82 patients with ICP (hospital ICP group) and 86 normal pregnant women (control group) were enrolled in this study. Retrospective control study was conducted on ICP risk factors analysis. [Results] Compared with the control group, the levels of estrogen, immune disorders, genetic factors and trace element selenium were significantly correlated with ICP, the difference was statistically significant (P <0.05). Multivariate regression analysis showed that estrogen levels, immune disorders, trace element selenium content of ICP risk factors. [Conclusion] The level of estrogen in the body, the imbalance of body immunity and the content of trace element selenium are the high risk factors of ICP. Active measures are taken for women with ICP to avoid the occurrence of postpartum complications.