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目的比较门冬胰岛素30单独三餐前应用与门冬胰岛素、甘精胰岛素联合4次/d应用治疗2型糖尿病的有效性和安全性临床疗效。方法将40例服用口服降糖药血糖控制不达标的成年2型糖尿病患者随机分为两组,每组20人,A组在三餐前注射门冬胰岛素30,B组在三餐前注射门冬胰岛素,并在夜晚10点注射甘精胰岛素,比较两组患者血糖控制的效果和低血糖发生情况。结果治疗后两组的全天血糖控制均较治疗前明显下降,且两组的低血糖事件发生次数相似。结论门冬胰岛素30单独应用和门冬胰岛素及甘精胰岛素联合应用两种降糖方案都可以更好地控制口服降糖药效果欠佳的2型糖尿病患者,而且低血糖事件发生次数少,无严重低血糖事件发生。
Objective To compare the efficacy and safety of insulin aspart 30 before meals with insulin aspart and insulin glargine 4 times daily in the treatment of type 2 diabetes mellitus. Methods Forty adults with type 2 diabetes mellitus who did not receive oral hypoglycemic agents for their glycemic control were randomly divided into two groups, 20 in each group. Group A received aspart insulin 30 before meals, while group B received insulin before meals Insulin insulin and insulin glargine at 10 o’clock in the evening, the two groups were compared the effect of glycemic control and hypoglycemia. Results After treatment, the control of blood glucose in the two groups was significantly lower than that before treatment, and the frequency of hypoglycaemia was similar in both groups. CONCLUSIONS: Both aspart insulin 30 alone and insulin aspart as well as insulin glargine both provide better control of patients with type 2 diabetes who are less effective in oral hypoglycemic agents and have fewer hypoglycemic episodes and none Severe hypoglycemia occurs.