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在塞内加尔的肝炎流行地区,进行了用乙型肝炎(HB)疫苗预防儿童早期带HBsAg状态的对照试验,该地儿童在2岁时HBsAg阳性者占17％,到6～7岁时则80％至少已有一种HBV感染的标志;为此,主动免疫应该在幼年早期进行。方法:按试验规划在划定地区村镇内,自出生到2岁为止的儿童,不论HBV感染与否,均包括在内。HB疫苗以无HBV颗粒和乙型肝炎e抗原阴性的无症状HBsAg携带者的血清,经物理化学方法提纯而制成。纯化的HBsAg标准滴度是1:1,024(被动血
In a hepatitis epidemic in Senegal, a controlled trial of hepatitis B vaccine in the prevention of early HBsAg in children was conducted, with 17% of HBsAg-positive children aged 2 years and 80% of those aged 6 to 7 years There has been at least one sign of HBV infection; for this reason, active immunization should be carried out in early childhood. Methods: According to the trial plan, children from birth to 2 years of age in villages and towns in the designated areas, regardless of HBV infection or not, were included. The HB vaccine was made by the physicochemical purification of serum from asymptomatic HBsAg carriers without HBV particles and hepatitis B e antigen negative. Purified HBsAg standard titer is 1: 1,024 (passive blood